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Science, VOLUME 388, ISSUE 6743, 11 APR 2025

?????388??6743??2025?4?11?

????Life Sciences

Targeted MYC2 stabilization confers citrus Huanglongbing resistance

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? ???PINGZHI ZHAO, HUAN YANG, YANWEI SUN, JINGYIN ZHANG, KAIXING GAO, JINBAO WU, CHENGRONG ZHU, CECE YIN, XIAOYUE CHEN,, AND JIAN YE

? ???https://www.science.org/doi/10.1126/science.adq7203

? ??????????????????????????????????????????????50???????????????????????????????????????????????????????????????AI??????????????????

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? Abstract?Huanglongbing (HLB) is a devastating citrus disease. In this work, we report an HLB resistance regulatory circuit in Citrus composed of an E3 ubiquitin ligase, PUB21, and its substrate, the MYC2 transcription factor, which regulates jasmonate-mediated defense responses. A helitron insertion in the PUB21 promoter introduced multiple MYC2-binding cis-elements to create a regulatory circuit linking the PUB21 activity with MYC2 degradation. Ectopic expression of a natural dominant-negative PUB21 paralog discovered in distant Citrus relatives stabilized MYC2 and conferred resistance to HLB. Antiproteolysis peptides (APPs), identified by artificial intelligence, stabilized MYC2 by binding and inhibiting PUB21 activity. A 14?amino acid peptide, APP3-14, molecularly controlled HLB in greenhouse and field trials. This approach represents a strategy to combat uncultivable pathogens through targeted disease resistance protein stabilization.

The genetic architecture of and evolutionary constraints on the human pelvic form

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? ???LIAOYI XU, EUCHARIST KUN, DEVANSH PANDEY, JOYCE Y. WANG, MARIANNE F. BRASIL, TARJINDER SINGH, AND VAGHEESH M. NARASIMHAN

? ???https://www.science.org/doi/10.1126/science.adq1521

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? Abstract?The obstetrical dile??a stems from a conflict between the optimal pelvic structure for bipedalism and what is required for successfully birthing infants with larger brains than previous hominins. However, the data required to test this theory have not been available. Xu et al. used the UK Biobank to disentangle the genetic basis of pelvic morphology. They found 180 genome sites associated with seven pelvic proportion phenotypes, as well as genetic correlations between pelvic proportions and traits such as osteoarthritis, walking speed, and back pain, giving insight into facets of the obstetrical dile??a.

???Physics

Beyond-classical computation in quantum simulation

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? ???ANDREW D. KING , ALBERTO NOCERA, MAREK M. RAMS, JACEK DZIARMAGA, ROELAND WIERSEMA, WILLIAM BERNOUDY, JACK RAYMOND, NITIN KAUSHAL, NICLAS HEINSDORF, AND MOHAMMAD H. AMIN

? ???https://www.science.org/doi/10.1126/science.ado6285

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? Abstract?Quantum computers should be able to solve certain problems that classical computers cannot; however, at the current stage of development, imperfections in quantum computing hardware diminish this comparative advantage. King et al. contrasted the performance of their quantum annealing processor to state-of-the-art classical simulations of topical problems such as the quantum dynamics of the transverse-field Ising model. The researchers found that across a range of graph topologies, the quantum processor was able to outperform classical simulations. The results provide a challenge to classical computing, in which method improvement has in the past tempered claims of quantum advantage.

Ultrahigh capacitive energy storage through dendritic nanopolar design

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? ???YAJING LIU, YANG ZHANG, JING WANG, CHAO YANG, HONGGUANG WANG, JUDITH L. MACMANUS-DRISCOLL, HAO YANG, PETER A. VAN AKEN, WEIWEI LI, AND CE-WEN NAN

? ???https://www.science.org/doi/10.1126/science.adt2703

?????????bevictor?????????????????????????????????????????????????????????????????????????????????????

???????????????DNP????????????????????????????????????????????????????????????????????

????DNP?????PbZr0.53Ti0.47O3-MgO?????7.4??/???????????215.8??/??????????????80.7%?????????????????????????

? Abstract?Electrostatic dielectric capacitors with ultrahigh power densities are sought after for advanced electronic and electrical systems owing to their ultrafast charge-discharge capability. However, low energy density resulting from low breakdown strength and suppressed polarization still remains a daunting challenge for practical applications. We propose a microstructural strategy with dendritic nanopolar (DNP) regions self-assembled into an insulator, which simultaneously enhances breakdown strength and high-field polarizability and minimizes energy loss and thus markedly improves energy storage performance and stability. For illustration, in this study, we achieved a high energy density of 215.8 joules per cubic centimeter with an efficiency of 80.7% at a high electric field of 7.4 megavolts per centimeter in a DNP structure?designed PbZr0.53Ti0.47O3-MgO film. The proposed strategy is generally applicable for development of high-performance dielectric microcapacitors.

??Chemistry

Circular 3D printing of high-performance photopolymers through dissociative network design

??????????????????????3D??

? ???BO YANG, TIANTIAN NI, JINGJUN WU, ZIZHENG FANG KEXUAN YANG, BEN HE, XINGQUN PU, GUANCONG CHEN, CHUJUN NI, AND TAO XIE

? ???https://www.science.org/doi/10.1126/science.ads3880

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?????????3D???????????????????????????????????????????????????????-????????????????????????3D???

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? Abstract?One approach for closed-loop plastics recycling relies on reverting polymers back into monomers because one can then make new plastics without loss of properties. This depolymerization requirement restricts the molecular design to making polymers with high mechanical performance. We report a three-dimensional (3D) printing chemistry through stepwise photopolymerization by forming dithioacetal bonds. The polymerized network can be transformed back into a photoreactive oligomer by dissociation of the dithioacetal bonds. This network-oligomer transformation is reversible, therefore allowing circular 3D printing using the same material. Our approach offers the flexibility of making modular adjustments in the design of the network backbone of a polymer. This allows access to fully recyclable elastomers, crystalline polymers, and rigid glassy polymers with high mechanical toughness, making them potentially suitable for diverse applications.

???Ecology

Pharmaceutical pollution influences river-to-sea migration in Atlantic salmon (Salmo salar)

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? ???JACK A. BRAND, MARCUS MICHELANGELI, SAMUEL J. SHRY, ELEANOR R. MOORE, ANEESH P. H. BOSE, DANIEL CERVENY, JAKE M. MARTIN, GUSTAV HELLSTR?M, ERIN S. MCCALLUM , AND MICHAEL G. BERTRAM

? ???https://www.science.org/doi/10.1126/science.adp7174

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? Abstract?Despite the growing threat of pharmaceutical pollution, we lack an understanding of whether and how such pollutants influence animal behavior in the wild. Using laboratory- and field-based experiments across multiple years in Atlantic salmon (Salmo salar; n = 730), we show that the globally detected anxiolytic pollutant clobazam accumulates in the brain of exposed fish and influences river-to-sea migration success. Clobazam exposure increased the speed with which fish passed through two hydropower dams along their migration route, resulting in more clobazam-exposed fish reaching the sea compared with controls. We argue that such effects may arise from altered shoaling behavior in fish exposed to clobazam. Drug-induced behavioral changes are expected to have wide-ranging consequences for the ecology and evolution of wild populations.

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